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After having their EFL Cup title dreams dashed in midweek, both Arsenal and West Ham United seek to regroup Saturday in a London derby at Olympic Stadium.Both teams fielded weakened sides in their quarterfinal matches and both unsurprisingly came up second-best. The Gunners (8-4-1) had their 19-match unbeaten streak in all competitions come to an end with a 2-0 home loss to Southampton -- their first defeat since opening with a 4-3 setback to Liverpool on Aug. 14 -- while the Hammers second match in four days at Old Trafford resulted in a 4-1 defeat to Manchester United that extended their overall winless streak to five (0-2-3).Arsenal manager Arsene Wenger overturned nearly his entire starting XI for the EFL Cup match, and their youthful inexperience showed against a Saints side that also made substantial changes since it is juggling Europa League commitments around domestic action. Wenger, who has never won the EFL Cup in his 20 years on the Arsenal touchline, was frustrated with his teams lack of cohesion and cutting edge -- especially in a sluggish first half when they conceded both goals.Its not only a disappointing night because were out, but its a disappointing night because the performance was disappointing, he said. I question our urgency level, our focus from the start on. It was not good enough and we paid for that.The run we want to keep in the Premier League, but I am very disappointed because there are questions on important things. You know, when you turn up in the first 45 minutes we played.The Gunners have won just once in their last five matches overall (1-3-1), raising concerns over whether this will wind up being like most recent years in which Arsenal -- currently fourth in the table but only three points adrift of frontrunners Chelsea -- are good enough to secure Champions League qualification and the riches that help perpetuate their success while failing to mount a serious charge at the Premier League title.Carl Jenkinson endured another torrid time at fullback, a position where he is third-choice due to injuries to Hector Bellerin and Mathieu Debuchy. He will likely get his second league start in this match since Bellerin is expected to be sidelined at least two more weeks and Debuchy has a hamstring ailment that could sideline him another month.Wenger has injury concerns about forward Olivier Giroud and influential holding midfielder Santi Carzola, as both were held out of Wednesdays match. Mohamed Elneny, who was subbed off at intermission due to illness, is expected to be available.As north London deals with the disappointment of a rare Gunners defeat, the gloom and misery continues on the east side of the city as the Hammers continue to be unable to put together consistent performances on a match-to-match basis.A lack of focus early in both halves cost West Ham dearly as they fell behind two minutes into the contest and then allowed a back-breaking go-ahead goal to Anthony Martial three minutes after intermission in Wednesdays setback.After the slow start, we recovered and looked good but you cant do the same, manager Slaven Bilic said. And we did. They (Manchester United) totally deserved it then after that. You just cant have that kind of start in a game like this.West Ham (3-3-7) are languishing perilously above the relegation spots in 16th, one point clear of the drop. They also have fresh injury concerns Michail Antonio and Aaron Cresswell were both subbed off during the match and are questionable for this match. One player Bilic must replace is forward Diafra Sakho, who has been ruled out the next six weeks with a thigh injury suffered after scoring early in Sundays draw versus Manchester United.That puts even more pressure on Dimitri Payet to begin following up on his breakout 2015-16 season in which he had 13 goals and 14 assists in all competitions. The France international has just two goals and five assists in this campaign.We have a tough game on Saturday and we have a couple of players who came off injured, but we wanted to preserve players for then and Dimitri Payet also, Bilic said. Its unbelievable that when we get a couple of injuries like the ones we got today (after them all season) and its very tough for us now.The Hammers ended a 15-match winless spell against Arsenal in all competitions in emphatic style last season, winning 2-0 at the Emirates on goals by Cheikou Koyate and Mauro Zarate on either side of halftime.In the return encounter at Upton Park, Andy Carroll ran riot with his aerial supremacy and had a hat trick in an eight-minute span around intermission, single-handedly rescuing West Ham from a two-goal deficit to provide a 3-2 lead. Laurent Koscielny, however, spared Arsenals blushes with an equaliser on 70 minutes to salvage a point for the Gunners.Arsenal were unbeaten in their last nine (7-2-0) at Boleyn Ground and 12-7-2 there in all competitions during the Premier League era. West Ham have yet to turn Olympic Park into an intimidating venue, taking just eight points from six matches (2-2-2) while being outscored 9-6. 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